Evaluation of Biochemical Parameters and Trace Elements in Type-2 Diabetic Patients

Ahmed Ibrahim, Wala Nasrat, Esam Abdulkader Elhefian

Abstract


Background: Diabetes mellitus (DM) is a common disease of pancreas, in which a high blood sugar level over prolonged period of time is observed. This study was conducted on random samples of diabetic patients (females) with type 2  diabetes mellitus and non-diabetic patients who used as a control group. Fasting blood samples (FBS) were collected for measurements of blood glucose, Glycosylated Hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), urea and creatinine. The zinc, copper, iron and chromium levels were also evaluated in the serum samples in this study.

Methods: After 5 ml of venous blood was collected from patients (after an overnight fast), the serum was carefully separated by centrifugation for analysis. Samples were taken from patients who had never been suffering from other diseases.

Results: Statistical analysis showed a significant positive correlation between blood glucose levels and HbA1c (P = 0.025). In addition, a decrease in zinc and chromium levels and an increase in iron and copper levels were observed in diabetic patients’ samples comparing with the control group.

Conclusion: It was observed that a significant positive relationship exists between blood glucose levels and HbA1c (P = 0.025). Also, the levels of blood sugar, HbA1c and creatinine were found to be affected significantly by iron.

Keywords: diabetes, biochemical parameters, trace elements


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DOI Prefix: 10.20286