A case of Genital Tuberculosis

Maryam Khayyat Khameneie, Nahid Arian pour


Background: genital tuberculosis is a misleading health problem.

Methods: Laparascopic surgery of a multiparous woman revealed a complex mass adhering to the pelvic floor. Collected samples were cultured for microbial infection. Polymerase Chain Reaction test was done for presence of Mycobacterium tuberculosis.

Results: Mantoux test and Polymerase Chain Reaction test were negative. Caseous necrosis on frozen section specimens were seen. Granulomatous inflammation composed of epithelial cells and multinucleated giant cells were found. Patient was cured with anti-tuberculosis treatment.

Conclusions: In the present case only histopathological investigation of the smear could detect the genital tuberculosis.

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Akbulut S, Yagmur Y, Bakir S, Sogutcu N, Yilmaz D, Senol A, et al. Appendicular tuberculosis: review of 155 published cases and a report of two cases. European Journal of Trauma and Emergency Surgery. 2010;36:579-85.

Gatongi DK, Gitau G, Kay V, Ngwenya S, Lafong C, Hasan A. Female genital tuberculosis. The Obstetrician & Gynaecologist. 2005;7:75-9.

Kumar P, Shah N, Singhal A, Chauhan D, Katoch V, Mittal S, et al. Association of tuberculous endometritis with infertility and other gynecological complaints of women in India. Journal of clinical microbiology. 2008;46:4068-70.

Altman LK. Progress slows in detection of new Tb cases 2008. Available from: Progress Slows in Detection of New TB Cases.

Akbulut S, Arikanoglu Z, Basbug M. Tubercular tubo-ovarian cystic mass mimicking acute appendicitis: a case report. J Med Case Rep. 2011;5:363. http://www.ncbi.nlm.nih.gov/pubmed/21831284

Kruijshaar ME, Abubakar I. Increase in extrapulmonary tuberculosis in England and Wales 1999-2006. Thorax. 2009;64:1090-5. http://www.ncbi.nlm.nih.gov/pubmed/19850965

Abebe M, Lakew M, Kidane D, Lakew Z, Kiros K, Harboe M. Female genital tuberculosis in Ethiopia. Int J Gynaecol Obstet. 2004;84:241-6. http://www.ncbi.nlm.nih.gov/pubmed/15001372

Gupta N, Sharma JB, Mittal S, Singh N, Misra R, Kukreja M. Genital tuberculosis in Indian infertility patients. Int J Gynaecol Obstet. 2007;97:135-8. http://www.ncbi.nlm.nih.gov/pubmed/17362955

Tripathy SN, Tripathy SN. Infertility and pregnancy outcome in female genital tuberculosis. Int J Gynaecol Obstet. 2002;76:159-63. http://www.ncbi.nlm.nih.gov/pubmed/11818110

Malik S. Genital tuberculosis and implantation in assisted reproduction. Reviews in Gynaecological Practice. 2003;3:160-4.

Singh N, Sumana G, Mittal S. Genital tuberculosis: a leading cause for infertility in women seeking assisted conception in North India. Arch Gynecol Obstet. 2008;278:325-7. http://www.ncbi.nlm.nih.gov/pubmed/18283475

McCartan DP, Fleming FJ, Grace PA. The management of right iliac fossa pain - is timing everything? Surgeon. 2010;8:211-7. http://www.ncbi.nlm.nih.gov/pubmed/20569941

Umoh A, Gabriel M. Genital tuberculosis with secondary infertility-a case report of successful treatment and subsequent livebirth in Uyo Nigeria. Journal of Medicine and Medical Sciences. 2011;2:839-42.

Relman DA, Falkow S, Petri Jr WA, Mann BJ, Huston CD, Hewlett EL, et al. Mandell, Douglas and Bennett's principles and practice of infectious diseases. Complement. 2000;77:22.

Soini H, Musser JM. Molecular diagnosis of mycobacteria. Clin Chem. 2001;47:809-14. http://www.ncbi.nlm.nih.gov/pubmed/11325882

Sadeghian A. Comparison of three methods for the identification of Mycobacteriumtuberculosis. International Journal of Agriculture and Biology (Pakistan). 2005.

Centers for Disease C, Prevention. Publication of survey results of assessment of state health agencies' readiness for 2000. MMWR Morb Mortal Wkly Rep. 1999;48:830. http://www.ncbi.nlm.nih.gov/pubmed/10507250

Diagnostic Standards and Classification of Tuberculosis in Adults and Children. This official statement of the American Thoracic Society and the Centers for Disease Control and Prevention was adopted by the ATS Board of Directors, July 1999. This statement was endorsed by the Council of the Infectious Disease Society of America, September 1999. Am J Respir Crit Care Med. 2000;161:1376-95. http://www.ncbi.nlm.nih.gov/pubmed/10764337

Beggs CB, Noakes CJ, Sleigh PA, Fletcher LA, Siddiqi K. The transmission of tuberculosis in confined spaces: an analytical review of alternative epidemiological models. Int J Tuberc Lung Dis. 2003;7:1015-26. http://www.ncbi.nlm.nih.gov/pubmed/14598959

Horna-Campos OJ, Sanchez-Perez HJ, Sanchez I, Bedoya A, Martin M. Public transportation and pulmonary tuberculosis, Lima, Peru. Emerg Infect Dis. 2007;13:1491-3. http://www.ncbi.nlm.nih.gov/pubmed/18257992

Pelvic Inflammatory Disease. Available from: http://www.emedicinehealth.com/pelvic_inflammatory_disease/page9_em.htm.

Afzali N, Ahmadi F, Akhbari F. Various hysterosalpingography findings of female genital tuberculosis: A case series. Iran J Reprod Med. 2013;11:519-24. http://www.ncbi.nlm.nih.gov/pubmed/24639787

Mishra A, Singhal A, Chauhan DS, Katoch VM, Srivastava K, Thakral SS, et al. Direct detection and identification of Mycobacterium tuberculosis and Mycobacterium bovis in bovine samples by a novel nested PCR assay: correlation with conventional techniques. J Clin Microbiol. 2005;43:5670-8. http://www.ncbi.nlm.nih.gov/pubmed/16272503

Prabhakar S, Mishra A, Singhal A, Katoch VM, Thakral SS, Tyagi JS, et al. Use of the hupB gene encoding a histone-like protein of Mycobacterium tuberculosis as a target for detection and differentiation of M. tuberculosis and M. bovis. J Clin Microbiol. 2004;42:2724-32. http://www.ncbi.nlm.nih.gov/pubmed/15184459

Swaminathan S, Umadevi P, Shantha S, Radhakrishnan A, Datta M. Sero diagnosis of tuberculosis in children using two ELISA kits. Indian J Pediatr. 1999;66:837-42. http://www.ncbi.nlm.nih.gov/pubmed/10798148

Ben-Selma W, Ben-Kahla I, Marzouk M, Ferjeni A, Ghezal S, Ben-Said M, et al. Rapid detection of Mycobacterium tuberculosis in sputum by Patho-TB kit in comparison with direct microscopy and culture. Diagn Microbiol Infect Dis. 2009;65:232-5. http://www.ncbi.nlm.nih.gov/pubmed/19729264

Alcaide Fernandez de Vega F. [New methods for mycobacteria identification]. Enferm Infecc Microbiol Clin. 2006;24 Suppl 1:53-7. http://www.ncbi.nlm.nih.gov/pubmed/17125669

Domínguez J, Blanco S, Lacoma A, García-Sierra N, Prat C, Ausina V. Utilidad de la biología molecular en el diagnóstico microbiológico de las infecciones por micobacterias. Enfermedades Infecciosas y Microbiología Clínica. 2008;26:33-41.

DOI: http://dx.doi.org/10.20286/nova-jmbs-040155


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DOI Prefix: 10.20286