A study of lipid profile Levels of Type II Diabetes Mellitus

Murwan Khalid Sabahelkhier, Mohammed Ali Awadllah, Atif Saeed Mohammed Idrees, Ali Abdel-Ghaffar Abel Rahheem Mohammed, Mohammed Abdel Rahman Idris


This study consists of two parts; the Part one is to evaluate the level of Blood glucose and lipid profile  among diabetic patients(121 patients) which are compared with non-diabetic subjects (60 persons)  and  part two is to correlate lipid profile with cardiovascular abnormalities among type II diabetic patients. The diabetic patients were collected from Jabir Aboeleiz Center for Diabetes (51.9±11.22 years). Sixty healthy non-diabetic subjects were chosen as controls (52.44±10.76years). Blood glucose, total cholesterol (TC), triglycerides (TG) and high density lipoprotein (HDL) were measured by enzymatic colorimetric methods in both groups, and low density lipoprotein cholesterol (LDL) was calculated for each sample. Among diabetic patients, there is high glucose level, serum total cholesterol, triglycerides and LDL cholesterol (p<0.5), while low level of HDL cholesterol was observed when compared to non-diabetic subjects. No statistically variation was found in the level of glucose and lipid profile between male and female diabetic patients. In our study, we have found that serum lipid - cholesterol, triglycerides and low-density lipoprotein - levels were significantly (p < 0.05) correlated to cardiovascular abnormalities, while HDL had shown a statistically non-significant correlation (p>0.05). The study concluded that higher level of cholesterol, triglyceride and LDL-cholesterol in diabetic patients compared to non-diabetic subjects with lower level of serum HDL-cholesterol in diabetic patient compared to non- diabetic subjects.

Keywords: Diabetic, Insulin, Mellitus and lipid.

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Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen AJ et al. Non fasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women.; 2007, 298(3):299-308. http://www.ncbi.nlm.nih.gov/pubmed/17635890

Garvey WT, Kwon S, Zheng D, Shaughnessy S, Wallace P and Hutto A et al. Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonance. Diabetes;2003, 52:453-62. http://www.ncbi.nlm.nih.gov/pubmed/12540621

Sarwar N, Danesh J, Eiriksdottir G, Sigurdsson G, Wareham N and Bingham S et al. Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. Circulation.; 2007, 115:4508. http://www.ncbi.nlm.nih.gov/pubmed/17190864

Elnasri HA and Ahmed AM.. Patterns of lipid changes among type 2 diabetes patients in Sudan. East Mediterr Health J; 2008, 14:314-24. http://www.ncbi.nlm.nih.gov/pubmed/18561723

Farmer JA. Diabetic dyslipidemia and atherosclerosis: evidence from clinical trials. Curr Diab Rep; 2008, 8:71-7

Firdous S and Khan MZ. Comparison of patterns of lipid profile in type-2 diabetics and non-diabetics. Ann King Edward Med Coll Mar; 2007, 13:84-7.

Trinder P. Determination of glucose in blood using glucose oxidase, with alternative, oxygen acceptor. Ann Clin Biochem, 1969, 6:24-27. http://www.ncbi.nlm.nih.gov/pubmed/5776547

Tiez NW.. Clinical guide laboratory tests. 3rd Ed. (W. B. Saunders eds. Philadelphia USA, 1995, 1995: 610.

Allain CC. Enzymatic determination of total serum cholesterol. Clin. Chem.,1974, 20:470

Grove TH. Effect of reagent pH on determination of high density lipoprotein cholesterol by precipitation with sodium phosphotungstate- magnesium. Clin Chem, 1979, 25:560-564. http://www.ncbi.nlm.nih.gov/pubmed/38018

Assmann G., Jabs HU, Kohnert V. and Nolete W. and Schriewer H. et al. LDL-cholesterol determination in blood serum following precipitation of LDL with polyvinyl sulfate. Clin Chem Acfa, 1984, 140: 77-83. http://www.ncbi.nlm.nih.gov/pubmed/6744629

Haq A, Rehman J, Mahmood R, Safi AJ, Ahmed Z and Arif S. et al. Pattern of lipid profile in type-2 diabetes mellitus patients. J Postgrad Med Inst;2006, 20:366-9

King H, Aubert RE, Herman WH. Et al. Global burden of diabetes,1995-2025: prevalence, numerical estimates, and projections. Diabetes Care; 1998, 21: 1414- 1431. http://www.ncbi.nlm.nih.gov/pubmed/9727886

IDFTFDH (International Diabetes Federation Task Force on Diabetes Health Economics. Diabetes health economics: facts, figures, and forecast, International Diabetes Federation, Brussels, 1997

Amos AF. McCarty, DJ., Zimmet P. et al. The rising global burden of diabetes and its complications: Diab. Med., 14 (Suppl.), 1997, S7-S8. http://www.ncbi.nlm.nih.gov/pubmed/9450510

DeFronzo RA. The triumvirate: beta cell, muscle, livec a collusion responsible for NIDDM .Diabetes.1988,37:667-687

Chatterjee MN and Shinde R. Text book of medical laboratory technology. Metabolism of carbohydrates. (Jaypee Brothers Medical publisher) Sixth edition. 2005, 266-330, Delhi-India

Del Prato S., Bonadonna, RC., Bosom, E. et al. Characterization cellular defects of insulin action in type2 (noninsulin dependent) diabetes mellitus. I Clininvest. 1993, 91:4M-494. http://www.ncbi.nlm.nih.gov/pubmed/8432857

Richard MB., Cdemargaret AP., Alan W ., Aleksandra V., Priscilla H. and Marc R. et al. Adjust to Target in Type2 Diabetes. Comparison o f a simple algorithm with carbohydrate counting for Adjustment o f mealtime insulin glulisine Diabetes Care.2008, 31:1305-131

Pari L and Latha M. Effect o f Cassia auriculata flowers on blood sugar levels, serum and tissue lipids in streptozotocin diabetic rats. Singapore M ed J; 2002, 43:617-2. http://www.ncbi.nlm.nih.gov/pubmed/12693765

Decode study group. European Diabetes Epidemiology Group. Glucose tolerance and mortality. Comparism o f WHO and American Diabetes Association diagnostic criteria. Lancet.1999, 354 (9174): 617 - 621. http://www.ncbi.nlm.nih.gov/pubmed/10466661

Simons LA., Simons J., Friedlander T., McCallum J. et al. Cholesterol and other lipids predict coronary heart disease and ischem ic stroke in the elderly but in those be-low 70 years. Atherosclerosis.2001, 12: 173-181. http://www.ncbi.nlm.nih.gov/pubmed/11689222

Ganong WF Review of Medical Physiology 21ed Endocrine Function of pancreas & Regulation of Carbohydrate Metabolism. 2003, 324-33.

Suryawanshi NP., Bhutey AK., Nagdeote AN., Jadhav AA., Manoorkar GS. et al. The study of lipid peroxide and lipid profile in diabetes mellitus. Indian Journal of Clinical Biochemistry.2006, 126-130. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3453770/

Bays H. Atherogenic dyslipidemia in type2 diabetes and metabolic syndrome: current and future treatment options. Br J Diabetes Vase Dis. 2003, 3(5): 356-360.

Shih KC., Kwak CF., Hwa CM. et al. Acipimox attenuates hypertriglyceredem ia in dislipidemic Non-insulin dependent diabetes mellitus patients without perturbation of insulin sensitivity and glycemic control. Diabetic Res. clin. pract.1997, 36 (2), 113-119

Gowri MS., Westhuyzem D., Bridges SR., Anderson JW. et al. Deceased protection by HDL from poorly controlled type2 diabetic subjects against LDL oxidation may be due to the abnormal com position o f HDL. Arteriosclerosis, Thrombosis, and Vascular Biology. 1999, 19:2226- 2233

DOI: http://dx.doi.org/10.20286/nova-jmbs-050203


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